Macario Sakay was born in 1870 in Tondo, Macario Sakay had a working-class background. He started out as an apprentice in a calesa manufacturing shop. He was also a tailor, a barber, and an actor in comedias and moro-moros. His participation in Tagalog dramas exposed him to the world of love, courage, and discipline.
In 1894, Sakay joined the Dapitan, Manila branch of the Katipunan. Due to his exemplary work, he became head of the branch. His nightly activities as an actor in comedias camouflaged his involvement with the Katipunan. Sakay assisted in the operation of the Katipunan press. During the early days of the Katipunan, Sakay worked with Andres Bonifacio and Emilio Jacinto. He fought side by side with Bonifacio in the hills of Morong (now Rizal) Province.